منابع مشابه
Teeing Up Transcription on CpG Islands
Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al., 2009; Hargreaves et al., 2009).
متن کاملCpG islands and the regulation of transcription.
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters. Shared DNA sequence features adapt CGIs for promoter function by destabili...
متن کاملCpG Islands: Starting Blocks for Replication and Transcription
The ongoing release of numerous genome sequences constitutes a scientific landmark that has transformed our way of thinking about the organization of living matter. The complete list of annotated genes that is finally at hand pushes us to a stage where we can now explore how genomes harmonize the regulation of gene expression with other processes that must concurrently take place along the geno...
متن کاملCpG islands--'a rough guide'.
Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing. CGI methylation also occurs in normal tissues a...
متن کاملNew twists on the epigenetics of CpG islands.
CpG islands are >200-bp stretches of DNA that have a significantly higher concentration of CpG dinucleotides than the bulk of the genome. Whereas 70%–80% of all CpG dinucleotides in the human genome are methylated, CpG islands by and large remain unmethylated (Cross and Bird 1995), with the exception of those associated with imprinted and X-linked genes (Razin and Cedar 1994). In this issue of ...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.06.028